Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors

Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors

Blog Article

Extrachromosomal DNA is a common cause of oncogene amplification in cancer.The non-chromosomal inheritance laguna 3hp dust collector of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients.The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, is incompletely understood.

We examined gene expression patterns of 870 tumors of varied histological types, to identify transcriptional correlates of ecDNA.Here, iphone 13 atlanta we show that ecDNA-containing tumors impact four major biological processes.Specifically, ecDNA-containing tumors up-regulate DNA damage and repair, cell cycle control, and mitotic processes, but down-regulate global immune regulation pathways.

Taken together, these results suggest profound alterations in gene regulation in ecDNA-containing tumors, shedding light on molecular processes that give rise to their development and progression.